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If you were prescribed morphine, it's important to understand how long the effects of the drug will last in your body. Health Conditions Discover Plan Connect. Oxycodone vs. Medically reviewed by Alan Carter, Pharm. OxyContin Side-by-side Effectiveness Cost and availability Side effects Interactions With other conditions Pregnancy and breastfeeding Takeaway Introduction There are many different types of pain that affect people in different ways.
Oxycodone and OxyContin. Side by side: Drug features. Immediate-release oxycodone OxyContin Why is it used? Treatment of moderate to severe pain, such as pain after surgery or from a severe injury Treatment of moderate to severe pain that usually is associated with the last stages of chronic diseases Is a generic version available? Yes No What are the brands? Oxaydo Roxicodone OxyContin What are forms? Immediate-release oral tablet Immediate-release oral capsule Immediate-release oral solution Extended-release tablet Can the capsule or tablet be opened, cut, or crushed?
Yes No What are the strengths? Immediate-release oral tablet: Generic: 5 mg, 10 mg, 15 mg, 20 mg, 30 mg Roxicodone brand : 5 mg, 15 mg, 30 mg Oxaydo brand : 5 mg, 7. Every four to six hours Every 12 hours Do I take it for long-term or short-term treatment? Short-term treatment, usually three days or fewer Long-term treatment How do I store it?
Cost, insurance coverage, and availability. Side effects. Use with other medical conditions. Use in pregnant or breastfeeding women. Read this next. Tramadol vs. Oxycodone Immediate Release and Controlled Release. Results: The pain relief rates with morphine, MS contin and oxycodone were The occurrence rates of adverse reactions were Conclusion: Morphine, MS contin and oxycodone give similar pain relief and adverse reaction rates but of all, morphine is the preferred drug for the treatment of cancer pain from the perspective of pharmacoeconomics.
J Pain Symptom Manag. Safety and efficacy of once-daily hydromorphone extended-release versus twice-daily oxycodone hydrochloride controlled-release in chinese patients with cancer pain: a phase 3, randomized, double-blind, multicenter study. J Pain. Comparison of the tolerability profile of controlled-release oral morphine and oxycodone for Cancer pain treatment. An open-label randomized controlled trial.
Symptoms during cancer pain treatment following WHO-guidelines: a longitudinal follow-up study of symptom prevalence, severity and etiology. Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression.
Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the dark Agouti rat. J Pharmacol Exp Ther.
Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Anti-nociception by spinal and systemic oxycodone: why does the route make a difference? Riviere PJ. Peripheral kappa-opioid agonists for visceral pain. Br J Pharmacol. Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study. Scand J Gastroenterol.
A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model. Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats. Kalso E. How different is oxycodone from morphine?
Mechanisms of morphine-induced immunosuppression: effect of acute morphine administration on lymphocyte trafficking. Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and mu 3 opiate receptor-dependent mechanism. J Neuroimmunol. Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study. Lethality of morphine in mice infected with toxoplasma gondii.
Effects of morphine dependence on the pathogenesis of swine herpesvirus infection. J Infect Dis. Immunomodulatory effects of in vitro exposure to morphine and its metabolites. Morphine-6b-glucuronide induces potent immunomodulation. Int Immunopharmacol. Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects.
Genetics and variability in opioid response. Oxymorphone revisited. Semin Anesth. Multiple loci modulate opioid therapy response for cancer pain.
Clin Cancer Res. Analgesia and central side-effects: two separate dimensions of morphine response. Br J Clin Pharmacol. Opioid genetics: the key to personalized pain control? Clin Genet.
Evolving knowledge of opioid genetics in cancer pain. Clin Oncol R Coll Radiol. Heiskanen T, Kalso E. Controlled-release oxycodone and morphine in cancer related pain. Controlled-release oxycodone compared with controlled-release morphine in the treatment of cancer pain: a randomized, double-blind, parallel-group study.
Randomized, double-blind, cross-over trial comparing safety and efficacy of oral controlled-release oxycodone with controlled-release morphine in patients with cancer pain. J Clin Oncol. Download references. The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
You can also search for this author in PubMed Google Scholar. Kai-Kai Guo made substantial contributions to conception and design of the study; Cheng-Qi Deng, Gui-Jun Lu and Guo-Li Zhao searched literature, extracted data from the collected literature and analyzed the data; Kai-Kai Guo wrote the manuscript; Gui-Jun Lu revised the manuscript; All authors approved the final version of the manuscript. Correspondence to Gui-Jun Lu. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Reprints and Permissions. Guo, KK. Comparison of analgesic effect of oxycodone and morphine on patients with moderate and advanced cancer pain: a meta-analysis. BMC Anesthesiol 18, Download citation. Received : 03 March Accepted : 21 August Published : 24 September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. This article has been updated. Methods A systematic search of online electronic databases, including PubMed, Embase, Cochrane library updated on October were conducted. Results In total, seven randomized clinical trials met our inclusion criteria. Conclusions In the current study, no remarkable difference was identified either in analgesic efficacy or in tolerability of oxycodone and morphine as the first-line therapy for patients with moderate to severe cancer pain.
Background The principle to treat cancer pain, the 3 step analgesic ladder, was developed by the World Health Organization WHO in Methods and materials Search strategy Two investigators independently searched electronic databases: Pubmed, Embase, Cochrane library up to October Quality assessment Two investigators separately rated the quality of the retrieved studies. Data extraction Two authors independently extracted the relevant data from each trial. Statistical analysis A sensitivity analysis was also performed to examine the impact on the overall results, depending on the heterogeneity across the included studies.
Results Overview of literature search and study characteristics A total of studies were retrieved initially for evaluation. Full size image. Table 1 the primary characteristics of the eligible studies in more detail Full size table. Pooled analysis of PRR comparing oxycodone with morphine on patients with cancer pain. Pooled analysis of API comparing oxycodone with morphine on patients with cancer pain.
Pooled analysis of WPI comparing oxycodone with morphine on patients with cancer pain. Pooled analysis of nausea comparing oxycodone with morphine on patients with cancer pain. Pooled analysis of vomiting comparing oxycodone with morphine on patients with cancer pain.
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